O. Babkina; L. Shevchenko; D. Matiukhin; I. Korobko
The article analyzes the current state of the problem of a significant increase in alcohol consumption by the population, which leads to an increase in the traumatism and mortality of persons of working age against acute and chronic alcohol intoxication. It has been demonstrated that if there is a suspicion of the presence of alcohol intoxication, comprehensive research methods for evaluating the general condition are promising, which are based on the study of anamnestic data, the study of medical records, the timing of alcohol abuse and its number, a detailed study of the mechanism of injury and the circumstances of its receipt, a thorough study of clinical symptoms and the results of laboratory studies, as well as in lethal cases, mandatory examination of the results of forensic medical examination of the corpse.
In the course of the study, it was shown that the biochemical method of investigation is expedient and reliable for solving the problem of diagnosing the presence of chronic alcohol intoxication and its effect on the morpho-functional state of a person. As a result of our research, it has been established that the most reliable among the biochemical indicators for assessing the functional state of the liver, which is most affected by chronic alcohol intoxication, are alanine aminotransferase, aspartate aminotransferase, total and direct bilirubin, which increase significantly with alcohol abuse. The pathology of the pancreas was studied with the enzyme α-amylase in the blood serum, which increased with alcohol and traumatic injuries.
Based on the results of the study, we developed and applied in practice a mathematical model and a computer program for detecting the presence of chronic alcohol intoxication in persons who died non-violent death, and also in the case of deaths from mechanical trauma.